While this primarily applies to netbooks without optical drives, it can apply to any PC that where the optical drive is missing or broken. You can indeed install from CD without any optical drive of any kind.
I ended up buying an MSI Wind 100 LXP+ instead of an MSI Wind 100xp. I don't know what the exact differences are, but they were the same price. I spent a few hours adding my preferred software to the netbook (which MSI still calls a notebook) and I'll tell you what I already installed and what I plan to install.
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